growth, regeneration promoted by the recently
Tuesday, April 13, 2010
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Scientists at Duke University Medical Center have identified a novel growth factor that stimulates growth and regeneration of hematopoietic (blood forming) stem cells the in culture and in laboratory animals. The discovery, que aparece en la revista Nature Medicine, los investigadores pueden ayudar a superar una de las barreras de la frustración a la terapia celular: el hecho de que las células madre son tan pocos en número y obstinadamente tan resistente a la expansión.
Los investigadores creen que la sangre del cordón umbilical podría servir como una fuente universal de las células madre para todos los pacientes que necesitan un trasplante de células madre, pero el número de células madre en las unidades de sangre del cordón umbilical son limitados, por lo que existe una necesidad clínica de desarrollar un método para ampliar sangre del cordón umbilical las células madre para trasplantes. "Desafortunadamente, no soluble growth factors identified to date that have been proven to extend human stem cells for therapeutic purposes, "said John Hopper, MD, a transplant physician stem cells and cell biologist at Duke and lead author .
Chute, in collaboration with Heather Himburg, post-doctoral fellow in his laboratory, found that the addition of pleiotrophin, a growth factor naturally stimulated a tenfold expansion of stem cells extracted from bone marrow a mouse.
pleiotrophin also found that increasing the number of cord blood human umbilical stem cells in culture that were able to graft in immunodeficient mice. When injected into mice that received radiation pleiotrophin bone marrow suppression, there was a 10-fold increase in bone marrow compared with untreated mice. "These results confirm that induce stem cells to regenerate after injury pleiotrophin," Chute said.
Chute says the finding could lead to wider application of transplantation of umbilical cord blood for the large number of patients who have no immune-matched donor "Perhaps most important, treatment systemic pleiotrophin may have the potential to accelerate the recovery of the blood and immune system in patients undergoing chemotherapy or radiotherapy, "he said.
Given the power of the effect on the expansion of pleiotrophin stem cells, the authors examined whether caused pleiotrophin blood-forming cells to become malignant. So far, Chute says that I have not seen any evidence of cancer in mice up to six months after treatment with pleiotrophin.
The Duke team is now conducting additional experiments to determine whether pleiotrophin is required for normal growth stem cells and development y Chute dice que será importante llevar a cabo estudios adicionales de los animales antes de entrar en ensayos clínicos humanos. "En este momento, cualquier progreso que puede hacer que nos ayuda a comprender mejor las vías biológicas que se activan en las células madre en respuesta a pleiotrophin ayudará a mover el descubrimiento hacia adelante".
Los investigadores creen que la sangre del cordón umbilical podría servir como una fuente universal de las células madre para todos los pacientes que necesitan un trasplante de células madre, pero el número de células madre en las unidades de sangre del cordón umbilical son limitados, por lo que existe una necesidad clínica de desarrollar un método para ampliar sangre del cordón umbilical las células madre para trasplantes. "Desafortunadamente, no soluble growth factors identified to date that have been proven to extend human stem cells for therapeutic purposes, "said John Hopper, MD, a transplant physician stem cells and cell biologist at Duke and lead author .
Chute, in collaboration with Heather Himburg, post-doctoral fellow in his laboratory, found that the addition of pleiotrophin, a growth factor naturally stimulated a tenfold expansion of stem cells extracted from bone marrow a mouse.
pleiotrophin also found that increasing the number of cord blood human umbilical stem cells in culture that were able to graft in immunodeficient mice. When injected into mice that received radiation pleiotrophin bone marrow suppression, there was a 10-fold increase in bone marrow compared with untreated mice. "These results confirm that induce stem cells to regenerate after injury pleiotrophin," Chute said.
Chute says the finding could lead to wider application of transplantation of umbilical cord blood for the large number of patients who have no immune-matched donor "Perhaps most important, treatment systemic pleiotrophin may have the potential to accelerate the recovery of the blood and immune system in patients undergoing chemotherapy or radiotherapy, "he said.
Given the power of the effect on the expansion of pleiotrophin stem cells, the authors examined whether caused pleiotrophin blood-forming cells to become malignant. So far, Chute says that I have not seen any evidence of cancer in mice up to six months after treatment with pleiotrophin.
The Duke team is now conducting additional experiments to determine whether pleiotrophin is required for normal growth stem cells and development y Chute dice que será importante llevar a cabo estudios adicionales de los animales antes de entrar en ensayos clínicos humanos. "En este momento, cualquier progreso que puede hacer que nos ayuda a comprender mejor las vías biológicas que se activan en las células madre en respuesta a pleiotrophin ayudará a mover el descubrimiento hacia adelante".
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